Research Articles
A One-Two Punch for Leukemia: How a New Drug Combo Exploits Cancer's Weakness
Discover how pevonedistat and belinostat work synergistically to combat Acute Myeloid Leukemia by disrupting DNA repair mechanisms and triggering cancer cell death.
Tomato's Secret Genome: How DNA Repair Proteins Shape Your Favorite Fruit
Discover how WD40-repeat proteins and DDB1 interactions shape tomato development, resilience, and flavor through cutting-edge genomic research.
Fanconi Anemia: The Story of a Cellular Superhero's Flaw
Explore Fanconi Anemia, a rare genetic disorder affecting DNA repair mechanisms. Learn about its causes, symptoms, and cutting-edge research.
Decoding the DNA Guardian: How a Tiny Domain in FANCD2 Helps Prevent Cancer
Explore how the CUE domain in FANCD2 protein acts as a master regulator in DNA repair and its implications for cancer prevention.
Disarming Cancer's Repair Crew: A New Tactic to Boost Radiation Therapy
Discover how TAK-243, a UAE inhibitor, disrupts DNA damage repair in cancer cells and enhances radiation therapy effectiveness.
The Cell's Librarian: How Histone H3 Orchestrates Cancer-Fighting DNA Repair
Discover how the overlooked Histone H3 protein directs BRCA1/BARD1 in DNA repair, revealing new insights into cancer prevention mechanisms.
The Ubiquitin Switch: How a Molecular Tag Regulates DNA Repair and Prevents Cancer
Explore how monoubiquitination regulates DNA polymerase η in translesion synthesis, a crucial DNA damage response mechanism with implications for cancer prevention and treatment.
The Silent Guardian: How Cells Shut Down Genes to Fix Broken DNA
Discover how BRD7 protein orchestrates transcriptional repression to enable DNA repair at active gene regions, a breakthrough in genome maintenance research.